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Article

Genetic variant burden and adverse outcomes in pediatric cardiomyopathy.

Pediatric research - 1 May 2021

Burstein Danielle S, Gaynor J William, Griffis Heather, Ritter Alyssa, Connor Matthew J O', Rossano Joseph W, Lin Kimberly Y, Ahrens-Nicklas Rebecca C

Abstract excerpt

BACKGROUND: Previous genetic research in pediatric cardiomyopathy (CM) has focused on pathogenic variants for diagnostic purposes, with limited data evaluating genotype-outcome correlations. We explored whether greater genetic variant burden (pathogenic or variants of unknown significance, VUS) correlates with worse outcomes. METHODS: Children with dilated CM (DCM) and hypertrophic CM (HCM) who underwent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32746448
DOI: 10.1038/s41390-020-1101-5
PMCID: PMC8256333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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