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Article

Donor genetic variants in interleukin-6 and interleukin-6 receptor associate with biopsy-proven rejection following kidney transplantation.

Scientific reports - 13 Aug 2021

Poppelaars Felix, Gaya da Costa Mariana, Eskandari Siawosh K, Damman Jeffrey, Seelen Marc A

Abstract excerpt

Rejection after kidney transplantation remains an important cause of allograft failure that markedly impacts morbidity. Cytokines are a major player in rejection, and we, therefore, explored the impact of interleukin-6 (IL6) and IL-6 receptor (IL6R) gene polymorphisms on the occurrence of rejection after renal transplantation. We performed an observational cohort study analyzing both donor and recipient DNA in...

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Identifiers

PMID: 34389747
DOI: 10.1038/s41598-021-95714-z
PMCID: PMC8363661

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