Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome.

Stem cell reports - 14 Sept 2021

Zhou Danni, Tan Ying, Liu Xiaoling, Tang Ling, Wang Hao, Shen Jiaxi, Wang Wei, Zhuang Lenan, Tao Juan, Su Jun, Gong Tingyu, Liu Xiaorong, Liang Ping, Yu Feng, Zhao Minghui

Abstract excerpt

Atypical hemolytic uremic syndrome (aHUS) is a rare disease associated with high morbidity and mortality. Existing evidence suggests that the central pathogenesis to aHUS might be endothelial cell damage. Nevertheless, the role of endothelial cell alterations in aHUS has not been well characterized and the underlying mechanisms remain unclear. Utilizing an induced pluripotent stem cell-derived endothelial cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atypical Hemolytic Uremic Syndrome
Share to Autoimmunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Factor H

Share to Endothelial Cells

Share to Endothelium

Share to Induced Pluripotent Stem Cells

Share to MAP Kinase Signaling System

Share to p38 Mitogen-Activated Protein Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 34388364
DOI: 10.1016/j.stemcr.2021.07.011
PMCID: PMC8452517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patient-specific iPSC-derived endothelial cells reveal aberrant p38 MAPK signaling in atypical hemolytic uremic syndrome.PMID 34388364Read ↗

Atypical hemolytic uremic syndrome, genetic basis, and clinical manifestations.Semantic proximity Read ↗

Consensus regarding diagnosis and management of atypical hemolytic uremic syndromeSemantic proximity Read ↗

Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient associations and regulatorsSemantic proximity Read ↗

A review of genetic and epigenetic biomarkers involved in the occurrence of atypical hemolytic uremic syndrome and its therapeutic strategies.Semantic proximity Read ↗

[Atypical hemolytic uremic syndrome].Semantic proximity Read ↗

Thrombotic microangiopathy: focus on atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Atypical Hemolytic Uremic SyndromeSemantic proximity Read ↗

Familial atypical hemolytic uremic syndrome: a review of its genetic and clinical aspects.Semantic proximity Read ↗

Complement mutations in diacylglycerol kinase-ε-associated atypical hemolytic uremic syndrome.Semantic proximity Read ↗

Atypical hemolytic uremic syndrome: Korean pediatric series.Semantic proximity Read ↗

Pediatric Atypical Hemolytic Uremic Syndrome Advances.Semantic proximity Read ↗

Loss of DGKε induces endothelial cell activation and death independently of complement activationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.