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Article

Stem Cell Factor SOX2 Confers Ferroptosis Resistance in Lung Cancer via Upregulation of SLC7A11.

Cancer research - 15 Oct 2021

Wang Xinbo, Chen Yueqing, Wang Xudong, Tian Hongling, Wang Yanjin, Jin Jiali, Shan Zezhi, Liu Yu'e, Cai Zhenyu, Tong Xinyuan, Luan Yi, Tan Xiao, Luan Bing, Ge Xin, Ji Hongbin, Jiang Xuejun, Wang Ping

Abstract excerpt

Ferroptosis is a lipid peroxidation-dependent cell death caused by metabolic dysfunction. Ferroptosis-associated enzymes are promising therapeutic targets for cancer treatment. However, such therapeutic strategies show limited efficacy due to drug resistance and other largely unknown underlying mechanisms. Here we report that cystine transporter SLC7A11 is upregulated in lung cancer stem-like cells (CSLC) and can...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34385181
DOI: 10.1158/0008-5472.CAN-21-0567
PMCID: PMC8530936

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