Article
Comparison of phenotypic antimicrobial susceptibility testing results and WGS-derived genotypic resistance profiles for a cohort of ESBL-producing Escherichia coli collected from Canadian hospitals: CANWARD 2007-18.
The Journal of antimicrobial chemotherapy - 11 Oct 2021
Golden Alyssa R, Karlowsky James A, Walkty Andrew, Baxter Melanie R, Denisuik Andrew J, McCracken Melissa, Mulvey Michael R, Adam Heather J, Bay Denice, Zhanel George G
Abstract excerpt
OBJECTIVES: To determine whether the genotypic resistance profile inferred from WGS could accurately predict phenotypic resistance for ESBL-producing Escherichia coli isolated from patient samples in Canadian hospital laboratories. METHODS: As part of the ongoing CANWARD study, 671 E. coli were collected and phenotypically confirmed as ESBL producers using CLSI M100 disc testing criteria. Isolates were sequenced...
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