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Article

Antibiotic resistance determination using Enterococcus faecium whole-genome sequences: a diagnostic accuracy study using genotypic and phenotypic data.

The Lancet. Microbe - 1 Feb 2024

Coll Francesc, Gouliouris Theodore, Blane Beth, Yeats Corin A, Raven Kathy E, Ludden Catherine, Khokhar Fahad A, Wilson Hayley J, Roberts Leah W, Harrison Ewan M, Horner Carolyne S, Le Thi Hoi, Nguyen Thi Hoa, Nguyen Vu Trung, Brown Nicholas M, Holmes Mark A, Parkhill Julian, Estee Török Mili, Peacock Sharon J

Abstract excerpt

BACKGROUND: DNA sequencing could become an alternative to in vitro antibiotic susceptibility testing (AST) methods for determining antibiotic resistance by detecting genetic determinants associated with decreased antibiotic susceptibility. Here, we aimed to assess and improve the accuracy of antibiotic resistance determination from Enterococcus faecium genomes for diagnosis and surveillance purposes. METHODS: In...

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PMID: 38219758
DOI: 10.1016/S2666-5247(23)00297-5

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