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Article

The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster.

Nature communications - 10 Aug 2021

Yoshinari Yuto, Kosakamoto Hina, Kamiyama Takumi, Hoshino Ryo, Matsuoka Rena, Kondo Shu, Tanimoto Hiromu, Nakamura Akira, Obata Fumiaki, Niwa Ryusuke

Abstract excerpt

The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the secretion of glucagon and insulins in mammals. Although glucagon-like and insulin-like hormones have been found across animal phyla, incretin-like EEC-derived hormones have not yet been characterised in invertebrates. Here, we show that the midgut-derived hormone, neuropeptide F (NPF), acts as the sugar-responsive,...

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Identifiers

PMID: 34376687
DOI: 10.1038/s41467-021-25146-w
PMCID: PMC8355161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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