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Article

Limited evolution of the actionable metastatic cancer genome under therapeutic pressure.

Nature medicine - 1 Sept 2021

van de Haar Joris, Hoes Louisa R, Roepman Paul, Lolkema Martijn P, Verheul Henk M W, Gelderblom Hans, de Langen Adrianus J, Smit Egbert F, Cuppen Edwin, Wessels Lodewyk F A, Voest Emile E

Abstract excerpt

Genomic profiling is critical for the identification of treatment options for patients with metastatic cancer, but it remains unclear how frequently this procedure should be repeated during the course of the disease. To address this, we analyzed whole-genome sequencing (WGS) data of 250 biopsy pairs, longitudinally collected over the treatment course of 231 adult patients with a representative variety of...

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PMID: 34373653
DOI: 10.1038/s41591-021-01448-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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