Article
[Characterization of a rare HLA-C*08:84 allele and analysis of its 3-D molecular structure].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 10 Aug 2021
Wang Tianju, Qi Jun, Li Hengxin, Hao Jian, Wang Xiaofang, Wang Manni, Fang Jie, Wu Junhua, Shang Lixia, Chen Le
Abstract excerpt
OBJECTIVE: To verify a rare allele of human leukocyte antigen (HLA) and analyze its inheritance and 3D molecular structure. METHODS: PCR-sequence-based typing, PCR-single strand oligonucleotide polymorphism and single allele-specific sequencing were carried out to characterize the rare HLA-C allele and its transmission in the family. Its protein structure was modeled by using SWISS-MODEL, Phyre2 and FATCAT...
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