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Article

DNMT1-mediated PPARα methylation aggravates damage of retinal tissues in diabetic retinopathy mice

6 Aug 2021

Abstract excerpt

BACKGROUND: Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα in DR. METHODS: Human retinal capillary pericytes (HRCPs) were treated with high glucose (HG) to induce DR cell model. DR mouse model was established by streptozotocin injection, and then...

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PMID: 34362460
DOI: 10.1186/s40659-021-00347-1

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