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Article

Unexpected plasticity in the life cycle of Trypanosoma brucei

6 Aug 2021

Abstract excerpt

African trypanosomes cause sleeping sickness in humans and nagana in cattle. These unicellular parasites are transmitted by the bloodsucking tsetse fly. In the mammalian host's circulation, proliferating slender stage cells differentiate into cell cycle-arrested stumpy stage cells when they reach high population densities. This stage transition is thought to fulfil two main functions: first, it auto-regulates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34355698
DOI: 10.7554/elife.66028

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