Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.

doi:10.1073/pnas.2015528118

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Article

Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis.

Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2021

García-Castillo Jesús, Alcaraz-Pérez Francisca, Martínez-Balsalobre Elena, García-Moreno Diana, Rossmann Marlies P, Fernández-Lajarín Miriam, Bernabé-García Manuel, Pérez-Oliva Ana B, Rodríguez-Cortez Virginia C, Bueno Clara, Adatto Isaac, Agarwal Suneet, Menéndez Pablo, Zon Leonard I, Mulero Victoriano, Cayuela María L

Abstract excerpt

Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition syndrome caused by mutations in telomerase or telomeric proteins. Here, we report that zebrafish telomerase RNA (terc) binds to specific DNA sequences of master myeloid genes and controls their expression by recruiting RNA Polymerase II (Pol II). Zebrafish terc harboring the CR4-CR5 domain mutation found in DC patients...

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Identifiers

PMID: 34353901
DOI: 10.1073/pnas.2015528118
PMCID: PMC8364177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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