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Exogenous <i>TERC</i> alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients

21 Nov 2008

Abstract excerpt

Dyskeratosis congenita (DC) is an inherited multi-system disorder characterised by muco-cutaneous abnormalities, bone marrow failure and a predisposition to malignancy. Bone marrow failure is the principal cause of mortality and is thought to be the result of premature cell death in the haematopoietic compartment because DC cells age prematurely and tend to have short telomeres. DC is genetically heterogeneous...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 19036115
DOI: 10.1111/j.1365-2141.2008.07516.x

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