Article
Reverse complement-PCR, an innovative and effective method for multiplexing forensically relevant single nucleotide polymorphism marker systems.
BioTechniques - 1 Sept 2021
Bus Magdalena M, de Jong Erik Ac, King Jonathan L, van der Vliet Walter, Theelen Joop, Budowle Bruce
Abstract excerpt
DNA analyses from challenging samples such as touch evidence, hairs and skeletal remains push the limits of the current forensic DNA typing technologies. Reverse complement PCR (RC-PCR) is a novel, single-step PCR target enrichment method adapted to amplify degraded DNA. The sample preparation process involves a limited number of steps, decreasing the labor required for library preparation and reducing the...
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