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Target capture enrichment of nuclear SNP markers for massively parallel sequencing of degraded and mixed samples.

Forensic science international. Genetics - 1 May 2018

Bose Nikhil, Carlberg Katie, Sensabaugh George, Erlich Henry, Calloway Cassandra

Abstract excerpt

DNA from biological forensic samples can be highly fragmented and present in limited quantity. When DNA is highly fragmented, conventional PCR based Short Tandem Repeat (STR) analysis may fail as primer binding sites may not be present on a single template molecule. Single Nucleotide Polymorphisms (SNPs) can serve as an alternative type of genetic marker for analysis of degraded samples because the targeted...

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PMID: 29524767
DOI: 10.1016/j.fsigen.2018.01.010

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