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Article

A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.

American journal of human genetics - 2 Sept 2021

Xu Mai, Mehl Lindsey, Zhang Tongwu, Thakur Rohit, Sowards Hayley, Myers Timothy, Jessop Lea, Chesi Alessandra, Johnson Matthew E, Wells Andrew D, Michael Helen T, Bunda Patricia, Jones Kristine, Higson Herbert, Hennessey Rebecca C, Jermusyk Ashley, Kovacs Michael A, Landi Maria Teresa, Iles Mark M, Goldstein Alisa M, Choi Jiyeon, Chanock Stephen J, Grant Struan F A, Chari Raj, Merlino Glenn, Law Matthew H, Brown Kevin M

Abstract excerpt

Genome-wide association studies (GWASs) have identified a melanoma-associated locus on chromosome band 7p21.1 with rs117132860 as the lead SNP and a secondary independent signal marked by rs73069846. rs117132860 is also associated with tanning ability and cutaneous squamous cell carcinoma (cSCC). Because ultraviolet radiation (UVR) is a key environmental exposure for all three traits, we investigated the...

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Share to Basic Helix-Loop-Helix Transcription Factors
Share to Carcinogenesis
Share to Chromosomes, Human, Pair 7
Share to Melanocytes
Share to Polychlorinated Dibenzodioxins
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Share to Receptors, Aryl Hydrocarbon
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Source

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Identifiers

PMID: 34343493
DOI: 10.1016/j.ajhg.2021.07.002
PMCID: PMC8456165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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