Article
Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.
Nature communications - 8 May 2018
Visconti Alessia, Duffy David L, Liu Fan, Zhu Gu, Wu Wenting, Chen Yan, Hysi Pirro G, Zeng Changqing, Sanna Marianna, Iles Mark M, Kanetsky Peter A, Demenais Florence, Hamer Merel A, Uitterlinden Andre G, Ikram M Arfan, Nijsten Tamar, Martin Nicholas G, Kayser Manfred, Spector Tim D, Han Jiali, Bataille Veronique, Falchi Mario
Abstract excerpt
The skin's tendency to sunburn rather than tan is a major risk factor for skin cancer. Here we report a large genome-wide association study of ease of skin tanning in 176,678 subjects of European ancestry. We identify significant association with tanning ability at 20 loci. We confirm previously identified associations at six of these loci, and report 14 novel loci, of which ten have never been associated with...
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