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Article

Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs.

PLoS genetics - 1 Aug 2021

Christen Matthias, Högler Sandra, Kleiter Miriam, Leschnik Michael, Weber Corinna, Thaller Denise, Jagannathan Vidhya, Leeb Tosso

Abstract excerpt

We investigated a hereditary cerebellar ataxia in Belgian Shepherd dogs. Affected dogs developed uncoordinated movements and intention tremor at two weeks of age. The severity of clinical signs was highly variable. Histopathology demonstrated atrophy of the CNS, particularly in the cerebellum. Combined linkage and homozygosity mapping in a family with four affected puppies delineated a 52 Mb critical interval....

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Source

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Identifiers

PMID: 34339417
DOI: 10.1371/journal.pgen.1009716
PMCID: PMC8360551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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