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Article

Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection.

Frontiers in immunology - 1 Jan 2021

Ma Ruixue, Zhang Xiaoxiao, Shu Jiayi, Liu Ziyu, Sun Wenjie, Hou Shiyuan, Lv Yunhua, Ying Qikang, Wang Fang, Jin Xia, Liu Rongrong, Wu Xingan

Abstract excerpt

Hantaan virus (HTNV) infects humans and causes hemorrhagic fever with renal syndrome (HFRS). The development of well-characterized animal models of HFRS could accelerate the testing of vaccine candidates and therapeutic agents and provide a useful tool for studying the pathogenesis of HFRS. Because NLRC3 has multiple immunoregulatory roles, we investigated the susceptibility of Nlrc3-/- mice to HTNV infection in...

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Identifiers

PMID: 34335602
DOI: 10.3389/fimmu.2021.692509
PMCID: PMC8322986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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