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Article

Gestational stress induces depressive-like and anxiety-like phenotypes through epigenetic regulation of BDNF expression in offspring hippocampus.

Epigenetics - 1 Jan 2016

Zheng Yu, Fan Weidong, Zhang Xianquan, Dong Erbo

Abstract excerpt

Exposure to stressful life events during pregnancy exerts profound effects on neurodevelopment and increases the risk for several neurodevelopmental disorders including major depression. The mechanisms underlying the consequences of gestational stress are complex and remain to be elucidated. This study investigated the effects of gestational stress on depressive-like behavior and epigenetic modifications in young...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26890656
DOI: 10.1080/15592294.2016.1146850
PMCID: PMC4846107

Genes

BDNF
DNMT1
HDAC1
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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