Article
Patients with hypertension-associated thrombotic microangiopathy may present with complement abnormalities.
Kidney international - 1 Jun 2017
Timmermans Sjoerd A M E G, Abdul-Hamid Myrurgia A, Vanderlocht Joris, Damoiseaux Jan G M C, Reutelingsperger Chris P, van Paassen Pieter
Abstract excerpt
Thrombotic microangiopathy (TMA) is a pattern of endothelial damage that can be found in association with diverse clinical conditions such as malignant hypertension. Although the pathophysiological mechanisms differ, accumulating evidence links complement dysregulation to various TMA syndromes and in particular the atypical hemolytic uremic syndrome. Here, we evaluated the role of complement in nine consecutive...
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