Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs.

doi:10.1182/blood.2025031268

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Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs.

Blood - 13 Aug 2026

Hakobyan Mariam, Langstein Jens, Ramos Medina María José, Kleinert Emely, Schönung Maximilian, Hartmann Mark, Rohdjess Hannah, Wojtarowicz Jessica, Staeble Sina, Türe Melissa, Pobiedonoscew Yasmine, Claus Rainer, Bullinger Lars, Oakes Christopher C, Zoldan Katharina, Cross Michael, Platzbecker Uwe, Kneisel Niclas, Raffel Simon, Germing Ulrich, Hoermann Gregor, Haas Simon, Rippe Karsten, Fröhling Stefan, Pusch Stefan, Plass Christoph, Milsom Michael D, Lipka Daniel B

Abstract excerpt

ABSTRACT: IDH1 and IDH2 are frequently mutated in various cancers, including acute leukemias. However, the distinct mechanisms by which mutant IDH1 or IDH2 drive hematopoietic neoplasms remain poorly understood. Here, we analyzed DNA methylation in IDH1- and IDH2-mutant acute myeloid leukemia and found neutrophil lineage-specific epigenetic alterations in IDH1-mutant patients that went along with severely...

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Share to Gene Expression Regulation, Leukemic

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Source

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Identifiers

PMID: 42200677
DOI: 10.1182/blood.2025031268

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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