Article
Creatine transporter deficiency impairs stress adaptation and brain energetics homeostasis.
JCI insight - 8 Sept 2021
Chen Hong-Ru, Zhang-Brotzge Xiaohui, Morozov Yury M, Li Yuancheng, Wang Siming, Zhang Helen Heju, Kuan Irena S, Fugate Elizabeth M, Mao Hui, Sun Yu-Yo, Rakic Pasko, Lindquist Diana M, DeGrauw Ton, Kuan Chia-Yi
Abstract excerpt
The creatine transporter (CrT) maintains brain creatine (Cr) levels, but the effects of its deficiency on energetics adaptation under stress remain unclear. There are also no effective treatments for CrT deficiency, the second most common cause of X-linked intellectual disabilities. Herein, we examined the consequences of CrT deficiency in brain energetics and stress-adaptation responses plus the effects of...
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