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Reduced antibody cross-reactivity following infection with B.1.1.7 than with parental SARS-CoV-2 strains

29 Jul 2021

Abstract excerpt

Background: The degree of heterotypic immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging variants and the success of vaccination campaigns, but remains incompletely understood. Methods: We examined the immunogenicity of SARS-CoV-2 variant B.1.1.7 (Alpha) that arose in the United Kingdom and spread globally. We determined titres...

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PMID: 34323691
DOI: 10.7554/elife.69317

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