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Article

Genetics and Functional Mechanisms of STAT3 Polymorphisms in Human Tuberculosis.

Frontiers in cellular and infection microbiology - 1 Jan 2021

Wang Feifei, Huang Guixian, Shen Ling, Peng Ying, Sha Wei, Chen Zheng W, Shen Hongbo

Abstract excerpt

Signal transducer and activator of transcription-3 (STAT3) plays an important role in biological balance. Our and others previous studies implied that STAT3 had a great effect on fast-acting innate immunity against tuberculosis (TB). We hypothesized that stat3 SNP down-regulation of STAT3 leads to a change in susceptibility to TB in humans. To test this hypothesis, we investigated STAT3 SNPs using SNP scan™...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34307193
DOI: 10.3389/fcimb.2021.669394
PMCID: PMC8294188

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