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Article

Phenotypic characterization of cell culture-derived hepatitis E virus subjected to different chemical treatments: Application in virus removal via nanofiltration.

Journal of virological methods - 1 Oct 2021

Ideno Shoji, Inoue Takamasa, Takahashi Kadue, Urayama Takeru, Maeno Hideki, Takeuchi Kaoru, Sakai Kaoru

Abstract excerpt

Safety evaluation for the hepatitis E virus (HEV) is required for plasma fractionation products. Plasma-derived HEV (pHEV) is quite unique in that it is associated with a lipid membrane, which, when stripped during manufacturing processes, induces morphological changes in the virus, making it difficult to select proper HEV phenotypes for clearance studies. We developed a convenient system for the preparation of a...

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Identifiers

PMID: 34302862
DOI: 10.1016/j.jviromet.2021.114244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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