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Article

Identification of LRRC46 as a novel candidate gene for high myopia.

Science China. Life sciences - 1 Sept 2024

Jiang Lingxi, Dai Chao, Wei Yao, Zhao Bo, Li Qi, Wu Zhengzheng, Zou Liang, Ye Zimeng, Yang Zhenglin, Huang Lulin, Shi Yi

Abstract excerpt

High myopia (HM) is the primary cause of blindness, with the microstructural organization and composition of collagenous fibers in the cornea and sclera playing a crucial role in the biomechanical behavior of these tissues. In a previously reported myopic linkage region, MYP5 (17q21-22), a potential candidate gene, LRRC46 (c.C235T, p.Q79X), was identified in a large Han Chinese pedigree. LRRC46 is expressed in...

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PMID: 38874710
DOI: 10.1007/s11427-024-2583-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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