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Article

G6PD distribution in sub-Saharan Africa and potential risks of using chloroquine/hydroxychloroquine based treatments for COVID-19.

The pharmacogenomics journal - 1 Dec 2021

da Rocha Jorge E B, Othman Houcemeddine, Tiemessen Caroline T, Botha Gerrit, Ramsay Michèle, Masimirembwa Collen, Adebamowo Clement, Choudhury Ananyo, Brandenburg Jean-Tristan, Matshaba Mogomotsi, Simo Gustave, Gamo Francisco-Javier, Hazelhurst Scott

Abstract excerpt

Chloroquine/hydroxychloroquine have been proposed as potential treatments for COVID-19. These drugs have warning labels for use in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Analysis of whole genome sequence data of 458 individuals from sub-Saharan Africa showed significant G6PD variation across the continent. We identified nine variants, of which four are potentially deleterious to...

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Source

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Identifiers

PMID: 34302047
DOI: 10.1038/s41397-021-00242-8
PMCID: PMC8299738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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