Article
Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches.
Malaria journal - 2 Aug 2018
Shitaye Getasew, Gadisa Endalamaw, Grignard Lynn, Shumie Girma, Chali Wakweya, Menberu Temesgen, Belachew Mulualem, Tegegn Getaneh, Challi Sagni, Curry Jonathan, Mahey Laleta, Hailu Tsegaye, Mamo Hassen, Menon Menakath, Balcha Taye, Aseffa Abraham, Drakeley Chris, Bousema Teun, Tadesse Fitsum G
Abstract excerpt
BACKGROUND: 8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant liver stages. Deployment of primaquine is thus of relevance for malaria elimination efforts but challenged by the widespread prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) in...
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