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Article

In vivo evolution of an emerging zoonotic bacterial pathogen in an immunocompromised human host.

Nature communications - 23 Jul 2021

Launay A, Wu C-J, Dulanto Chiang A, Youn J-H, Khil P P, Dekker J P

Abstract excerpt

Zoonotic transfer of animal pathogens to human hosts can generate novel agents, but the genetic events following such host jumps are not well studied. Here we characterize the mechanisms driving adaptive evolution of the emerging zoonotic pathogen Bordetella hinzii in a patient with interleukin-12 receptor β1 deficiency. Genomic sequencing of 24 B. hinzii isolates cultured from blood and stool over 45 months...

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Source

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Identifiers

PMID: 34301946
DOI: 10.1038/s41467-021-24668-7
PMCID: PMC8302680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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