Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

doi:10.1038/nmicrobiol.2015.23

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Article

Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.

Nature microbiology - 1 Mar 2016

Klemm Elizabeth J, Gkrania-Klotsas Effrossyni, Hadfield James, Forbester Jessica L, Harris Simon R, Hale Christine, Heath Jennifer N, Wileman Thomas, Clare Simon, Kane Leanne, Goulding David, Otto Thomas D, Kay Sally, Doffinger Rainer, Cooke Fiona J, Carmichael Andrew, Lever Andrew Ml, Parkhill Julian, MacLennan Calman A, Kumararatne Dinakantha, Dougan Gordon, Kingsley Robert A

Abstract excerpt

Host adaptation is a key factor contributing to the emergence of new bacterial, viral and parasitic pathogens. Many pathogens are considered promiscuous because they cause disease across a range of host species, while others are host-adapted, infecting particular hosts1. Host adaptation can potentially progress to host restriction where the pathogen is strictly limited to a single host species and is frequently...

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PMID: 27127642
DOI: 10.1038/nmicrobiol.2015.23
PMCID: PMC4843968

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