Article
Risk of Late-Onset Breast Cancer in Genetically Predisposed Women.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Nov 2021
Boddicker Nicholas J, Hu Chunling, Weitzel Jeffrey N, Kraft Peter, Nathanson Katherine L, Goldgar David E, Na Jie, Huang Hongyan, Gnanaolivu Rohan D, Larson Nicole, Yussuf Amal, Yao Song, Vachon Celine M, Trentham-Dietz Amy, Teras Lauren, Taylor Jack A, Scott Christopher E, Sandler Dale P, Pesaran Tina, Patel Alpa V, Palmer Julie R, Ong Irene M, Olson Janet E, O'Brien Katie, Neuhausen Susan, Martinez Elena, Ma Huiyan, Lindstrom Sara, Le Marchand Loic, Kooperberg Charles, Karam Rachid, Hunter David J, Hodge James M, Haiman Christopher, Gaudet Mia M, Gao Chi, LaDuca Holly, Lacey James V, Dolinsky Jill S, Chao Elizabeth, Carter Brian D, Burnside Elizabeth S, Bertrand Kimberly A, Bernstein Leslie, Auer Paul W, Ambrosone Christine, Yadav Siddhartha, Hart Steven N, Polley Eric C, Domchek Susan M, Couch Fergus J
Abstract excerpt
PURPOSE: The prevalence of germline pathogenic variants (PVs) in established breast cancer predisposition genes in women in the general population over age 65 years is not well-defined. However, testing guidelines suggest that women diagnosed with breast cancer over age 65 years might have < 2.5% likelihood of a PV in a high-penetrance gene. This study aimed to establish the frequency of PVs and remaining risks...
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