Article
Early detection of metastatic uveal melanoma by the analysis of tumor-specific mutations in cell-free plasma DNA.
Cancer medicine - 1 Sept 2021
Le Guin Claudia H D, Bornfeld Norbert, Bechrakis Nikolaos E, Jabbarli Leyla, Richly Heike, Lohmann Dietmar R, Zeschnigk Michael
Abstract excerpt
BACKGROUND: Eye salvaging therapy of malignant melanomas of the uvea can preserve the eye in most cases, but still about half of patients die from metastatic disease. Previous analyses of cell-free DNA from plasma had shown detectable levels of tumor-specific GNAQ/GNA11 mutations in patients with the clinical diagnosis of progressive disease. However, data on the time span that elapses from the detection of ctDNA...
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