Article
Increased PD-1 Level in Severe Cervical Injury Is Associated With the Rare Programmed Cell Death 1 (PDCD1) rs36084323 A Allele in a Dominant Model.
Frontiers in cellular and infection microbiology - 1 Jan 2021
da Silva Mauro César, Medeiros Fernanda Silva, da Silva Neila Caroline Henrique, Paiva Larissa Albuquerque, Gomes Fabiana Oliveira Dos Santos, Costa E Silva Matheus, Gomes Thailany Thays, Peixoto Christina Alves, Rygaard Maria Carolina Valença, Menezes Maria Luiza Bezerra, Welkovic Stefan, Donadi Eduardo Antônio, Lucena-Silva Norma
Abstract excerpt
The high-risk oncogenic human papillomavirus (HPV) has developed mechanisms for evasion of the immune system, favoring the persistence of the infection. The chronic inflammation further contributes to the progression of tissue injury to cervical cancer. The programmed cell death protein (PD-1) after contacting with its ligands (PD-L1 and PD-L2) exerts an inhibitory effect on the cellular immune response,...
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