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Article

Role of inflammasome genetics in susceptibility to HPV infection and cervical cancer development.

Journal of medical virology - 1 Sept 2016

Pontillo A, Bricher P, Leal V N C, Lima S, Souza P R E, Crovella S

Abstract excerpt

PROBLEM: Only a small proportion of HPV+ women develop virus-associated lesions and cervical cancer, suggesting that other factors are involved in HPV+ keratinocyte transformation. Immune response plays an important role in clearing HPV infection, and host genetic variants resulting in defective immune response have been associated with virus persistence and/or cervical cancer. Considering that genetic variations...

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Source

Identifiers

PMID: 26945813
DOI: 10.1002/jmv.24514

Genes

NLRP3
NLRP1
CARD8
NLRP6
TNFAIP3

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