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Article

Role of titin in cardiomyopathy: from DNA variants to patient stratification.

Nature reviews. Cardiology - 1 Apr 2018

Ware James S, Cook Stuart A

Abstract excerpt

Dilated cardiomyopathy (DCM) affects approximately 1 in 250 individuals and is the leading indication for heart transplantation. DCM is often familial, and the most common genetic predisposition is a truncating variation in the giant sarcomeric protein, titin, which occurs in up to 15% of ambulant patients with DCM and 25% of end-stage or familial cases. In this article, we review the evidence for the role of...

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Identifiers

PMID: 29238064
DOI: 10.1038/nrcardio.2017.190

Genes

TTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Role of titin in cardiomyopathy: from DNA variants to patient stratification.PMID 29238064Read ↗

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Titin : an analysis of genetic variation and cardiac phenotypeSemantic proximity Read ↗

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