Histopathology is required to identify and characterize myopathies in high-throughput phenotype screening of genetically engineered mice.

Abstract excerpt

The development of mouse models that replicate the genetic and pathological features of human disease is important in preclinical research because these types of models enable the completion of meaningful pharmacokinetic, safety, and efficacy studies. Numerous relevant mouse models of human disease have been discovered in high-throughput screening programs, but there are important specific phenotypes revealed by...

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