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Article

Data integration uncovers the metabolic bases of phenotypic variation in yeast.

PLoS computational biology - 1 Jul 2021

Petrizzelli Marianyela Sabina, de Vienne Dominique, Nidelet Thibault, Noûs Camille, Dillmann Christine

Abstract excerpt

The relationship between different levels of integration is a key feature for understanding the genotype-phenotype map. Here, we describe a novel method of integrated data analysis that incorporates protein abundance data into constraint-based modeling to elucidate the biological mechanisms underlying phenotypic variation. Specifically, we studied yeast genetic diversity at three levels of phenotypic complexity...

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Identifiers

PMID: 34264947
DOI: 10.1371/journal.pcbi.1009157
PMCID: PMC8315545

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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