Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression.

doi:10.1038/s41408-021-00520-5

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Article

Biological significance of monoallelic and biallelic BIRC3 loss in del(11q) chronic lymphocytic leukemia progression.

Blood cancer journal - 9 Jul 2021

Quijada-Álamo Miguel, Hernández-Sánchez María, Rodríguez-Vicente Ana-Eugenia, Pérez-Carretero Claudia, Rodríguez-Sánchez Alberto, Martín-Izquierdo Marta, Alonso-Pérez Verónica, García-Tuñón Ignacio, Bastida José María, Vidal-Manceñido María Jesús, Galende Josefina, Aguilar Carlos, Queizán José Antonio, González-Gascón Y Marín Isabel, Hernández-Rivas José-Ángel, Benito Rocío, Ordóñez José Luis, Hernández-Rivas Jesús-María

Abstract excerpt

BIRC3 is monoallelically deleted in up to 80% of chronic lymphocytic leukemia (CLL) cases harboring del(11q). In addition, truncating mutations in the remaining allele of this gene can lead to BIRC3 biallelic inactivation, which has been shown to be a marker for reduced survival in CLL. Nevertheless, the biological mechanisms by which these lesions could contribute to del(11q) CLL pathogenesis and progression are...

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PMID: 34244476
DOI: 10.1038/s41408-021-00520-5
PMCID: PMC8270906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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