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Article

CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition.

Leukemia - 1 Jun 2020

Quijada-Álamo Miguel, Hernández-Sánchez María, Alonso-Pérez Verónica, Rodríguez-Vicente Ana E, García-Tuñón Ignacio, Martín-Izquierdo Marta, Hernández-Sánchez Jesús María, Herrero Ana B, Bastida José María, San Segundo Laura, Gruber Michaela, García Juan Luis, Yin Shanye, Ten Hacken Elisa, Benito Rocío, Ordóñez José Luis, Wu Catherine J, Hernández-Rivas Jesús María

Abstract excerpt

The deletion of 11q (del(11q)) invariably comprises ATM gene in chronic lymphocytic leukemia (CLL). Concomitant mutations in this gene in the remaining allele have been identified in 1/3 of CLL cases harboring del(11q), being the biallelic loss of ATM associated with adverse prognosis. Although the introduction of targeted BCR inhibition has significantly favored the outcomes of del(11q) patients, responses of...

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Identifiers

PMID: 31974435
DOI: 10.1038/s41375-020-0714-3
PMCID: PMC7266745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CRISPR/Cas9-generated models uncover therapeutic vulnerabilities of del(11q) CLL cells to dual BCR and PARP inhibition.PMID 31974435Read ↗

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