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Targeting autophagy in disease: established and new strategies

9 Jul 2021

Abstract excerpt

Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing cytosolic aggregated proteins, damaged organelles or invading microorganisms. Dysfunctional autophagy leads to pathological accumulation of the cargo, which has been linked to a range of human diseases, including neurodegenerative diseases, infectious and autoimmune diseases and various forms of cancer. Cumulative work in...

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PMID: 34241570
DOI: 10.1080/15548627.2021.1936359

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