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Article

Autophagy in disease: a double-edged sword with therapeutic potential

2 Apr 2009

Abstract excerpt

Autophagy is a catabolic trafficking pathway for bulk destruction and turnover of long-lived proteins and organelles via regulated lysosomal degradation. In eukaryotic cells, autophagy occurs constitutively at low levels to perform housekeeping functions, such as the destruction of dysfunctional organelles. Up-regulation occurs in the presence of external stressors (e.g. starvation, hormonal imbalance and...

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PMID: 19323652
DOI: 10.1042/cs20080508

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