Article
Integration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease.
Genome biology - 6 Jul 2021
Chu Xiaojing, Jaeger Martin, Beumer Joep, Bakker Olivier B, Aguirre-Gamboa Raul, Oosting Marije, Smeekens Sanne P, Moorlag Simone, Mourits Vera P, Koeken Valerie A C M, de Bree Charlotte, Jansen Trees, Mathews Ian T, Dao Khoi, Najhawan Mahan, Watrous Jeramie D, Joosten Irma, Sharma Sonia, Koenen Hans J P M, Withoff Sebo, Jonkers Iris H, Netea-Maier Romana T, Xavier Ramnik J, Franke Lude, Xu Cheng-Jian, Joosten Leo A B, Sanna Serena, Jain Mohit, Kumar Vinod, Clevers Hans, Wijmenga Cisca, Netea Mihai G, Li Yang
Abstract excerpt
BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors. RESULT: We systematically investigate circulating metabolites in a cohort of 500 healthy subjects (500FG) in whom immune function and activity are deeply measured and whose genetics are profiled. Our data reveal that several major...
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