Article
Transdifferentiation of mantle cell lymphoma into sarcoma with limited neuromuscular differentiation after conventional chemotherapy.
Virchows Archiv : an international journal of pathology - 1 May 2022
Kawashima Ichiro, Oishi Naoki, Kasai Kazunari, Inoue Tomohiro, Hosokawa Eriko, Nakadate Ayato, Matsuura Minori, Kumagai Takuma, Koshiishi Megumi, Yamamoto Takeo, Nakajima Kei, Tanaka Masaru, Kondo Tetsuo, Kirito Keita
Abstract excerpt
We report an exceptionally rare case of mantle cell lymphoma (MCL) that transdifferentiated into sarcoma with limited neuromuscular differentiation. An 81-year-old man with t(11;14)-positive MCL was treated with rituximab and bendamustine and achieved complete remission; however, just 2 months later, the patient developed multiple systemic tumors. Pathologic studies revealed round cell sarcoma expressing...
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