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Article

Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner.

Cell death & disease - 5 Jul 2021

Breuls Natacha, Giarratana Nefele, Yedigaryan Laura, Garrido Gabriel Miró, Carai Paolo, Heymans Stephane, Ranga Adrian, Deroose Christophe, Sampaolesi Maurilio

Abstract excerpt

Muscular dystrophies are debilitating neuromuscular disorders for which no cure exists. As this disorder affects both cardiac and skeletal muscle, patients would benefit from a cellular therapy that can simultaneously regenerate both tissues. The current protocol to derive bipotent mesodermal progenitors which can differentiate into cardiac and skeletal muscle relies on the spontaneous formation of embryoid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle Fibers, Skeletal

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Identifiers

PMID: 34226515
DOI: 10.1038/s41419-021-03936-w
PMCID: PMC8257578

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