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Article

Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1.

The Journal of allergy and clinical immunology - 1 Nov 2020

Lee Pui Y, Platt Craig D, Weeks Sabrina, Grace Rachael F, Maher George, Gauthier Kasey, Devana Sridevi, Vitali Sally, Randolph Adrienne G, McDonald Douglas R, Geha Raif S, Chou Janet

Abstract excerpt

BACKGROUND: We studied 2 unrelated patients with immune thrombocytopenia and autoimmune hemolytic anemia in the setting of acute infections. One patient developed multisystem inflammatory syndrome in children in the setting of a severe acute respiratory syndrome coronavirus 2 infection. OBJECTIVES: We sought to identify the mechanisms underlying the development of infection-driven autoimmune cytopenias. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Suppressor of Cytokine Signaling 1 Protein

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Source

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Identifiers

PMID: 32853638
DOI: 10.1016/j.jaci.2020.07.033
PMCID: PMC7445138

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