Pathogenic variants in actionable MODY genes are associated with type 2 diabetes.

doi:10.1038/s42255-020-00294-3

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Article

Pathogenic variants in actionable MODY genes are associated with type 2 diabetes.

Nature metabolism - 1 Oct 2020

Bonnefond Amélie, Boissel Mathilde, Bolze Alexandre, Durand Emmanuelle, Toussaint Bénédicte, Vaillant Emmanuel, Gaget Stefan, Graeve Franck De, Dechaume Aurélie, Allegaert Frédéric, Guilcher David Le, Yengo Loïc, Dhennin Véronique, Borys Jean-Michel, Lu James T, Cirulli Elizabeth T, Elhanan Gai, Roussel Ronan, Balkau Beverley, Marre Michel, Franc Sylvia, Charpentier Guillaume, Vaxillaire Martine, Canouil Mickaël, Washington Nicole L, Grzymski Joseph J, Froguel Philippe

Abstract excerpt

Genome-wide association studies have identified 240 independent loci associated with type 2 diabetes (T2D) risk, but this knowledge has not advanced precision medicine. In contrast, the genetic diagnosis of monogenic forms of diabetes (including maturity-onset diabetes of the young (MODY)) are textbook cases of genomic medicine. Recent studies trying to bridge the gap between monogenic diabetes and T2D have been...

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PMID: 33046911
DOI: 10.1038/s42255-020-00294-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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