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Article

FUT6 deficiency compromises basophil function by selectively abrogating their sialyl-Lewis x expression.

Communications biology - 2 Jul 2021

Puan Kia Joo, San Luis Boris, Yusof Nurhashikin, Kumar Dilip, Andiappan Anand Kumar, Lee Wendy, Cajic Samanta, Vuckovic Dragana, Chan Jing De, Döllner Tobias, Hou Han Wei, Jiang Yunxuan, Tian Chao, Rapp Erdmann, Poidinger Michael, Wang De Yun, Soranzo Nicole, Lee Bernett, Rötzschke Olaf

Abstract excerpt

Sialyl-Lewis x (sLex, CD15s) is a tetra-saccharide on the surface of leukocytes required for E-selectin-mediated rolling, a prerequisite for leukocytes to migrate out of the blood vessels. Here we show using flow cytometry that sLex expression on basophils and mast cell progenitors depends on fucosyltransferase 6 (FUT6). Using genetic association data analysis and qPCR, the cell type-specific defect was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34215830
DOI: 10.1038/s42003-021-02295-8
PMCID: PMC8253766

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