Article
Detection of Multiple Breast Cancer ESR1 Mutations on an ISFET Based Lab-on-Chip Platform.
IEEE transactions on biomedical circuits and systems - 1 Jun 2021
Alexandrou George, Moser Nicolas, Mantikas Katerina-Theresa, Rodriguez-Manzano Jesus, Ali Simak, Coombes R Charles, Shaw Jacqui, Georgiou Pantelis, Toumazou Christopher, Kalofonou Melpomeni
Abstract excerpt
ESR1 mutations are important biomarkers in metastatic breast cancer. Specifically, p.E380Q and p.Y537S mutations arise in response to hormonal therapies given to patients with hormone receptor positive (HR+) breast cancer (BC). This paper demonstrates the efficacy of an ISFET based CMOS integrated Lab-on-Chip (LoC) system, coupled with variant-specific isothermal amplification chemistries, for detection and...
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