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Article

Sensitive quantitation of ESR1 mutations in cell-free DNA from breast cancer patients using base-specific invasive reaction assisted qPCR.

Journal of pharmaceutical and biomedical analysis - 15 Apr 2021

Wang Chen, Zeng Huijuan, Zhang Luning, Shen Yiyun, Zou Bingjie, Wang Shaohua, Song Qinxin, Zhou Guohua

Abstract excerpt

Acquired estrogen receptor 1 (ESR1) mutation is being promoted as a key mechanism of resistance to endocrine therapies in breast cancers. It is significative to monitor ESR1 mutations in real time, which provide an opportunity to alter therapy as these mutations emerge. Previous assays based on next-generation sequencing (NGS) and digital PCR (dPCR) usually due to high costs and complicated workflows hampered...

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Identifiers

PMID: 33626444
DOI: 10.1016/j.jpba.2021.113959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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